A critical review on shelf life of Ayurvedic dosage form w.s.r. to Sneha Kalpana

Ayurveda is an ancient science that has many branches. The branch which deals with the herbal drug and used in the form of medicine to cure the disease is known as Bhaishajya Kalpana. Acharya Charaka quoted "Sansakaro hi nam Gunantaradhan" in Vimanasthana, which means because of the process on herbal drug Gunvardhana occurs. Also, the shelf life of formulations increases. Shelf life (Saviryataavadhi) means the period during which the potency (Virya) of the drug remains unaffected due to environmental factors or from microbial contamination. Different dosage forms have different Shelf period. This paper is given a detailed study of the literature review of the shelf life of Sneha Kalpana

Analysis of the Efficacy of Real-Time Hand Gesture Detection with Hog and Haar-Like Features Using SVM Classification

The field of hand gesture recognition has recently reached new heights thanks to its widespread use in domains like remote sensing, robotic control, and smart home appliances, among others. Despite this, identifying gestures is difficult because of the intransigent features of the human hand, which make the codes used to decode them illegible and impossible to compare. Differentiating regional patterns is the job of pattern recognition. Pattern recognition is at the heart of sign language. People who are deaf or mute may understand the spoken language of the rest of the world by learning sign language. Any part of the body may be used to create signs in sign language. The suggested system employs a gesture recognition system trained on Indian sign language. The methods of preprocessing, hand segmentation, feature extraction, gesture identification, and classification of hand gestures are discussed in this work as they pertain to hand gesture sign language. A hybrid approach is used to extract the features, which combines the usage of Haar-like features with the application of Histogram of Oriented Gradients (HOG).The SVM classifier is then fed the characteristics it has extracted from the pictures in order to make an accurate classification. A false rejection error rate of 8% is achieved while the accuracy of hand gesture detection is improved by 93.5%

Quantitative assessment of expression of cell adhesion molecule (CD44) splice variants: CD44 standard (CD44s) and v5, v6 isoforms in oral leukoplakias: An immunohistochemical study

Aim: The aim of this study was to semiquantitatively analyze the immunohistochemical expression pattern of CD44 standard (CD44s) and variant (CD44v) isoforms in leukoplakias using a panel of monoclonal antibodies recognizing epitopes of CD44s and of the variant exons v5 and v6. Objective: To evaluate the efficacy of CD44s and CD44 v5, v6 immunoexpression as possible molecular markers in detecting high-risk leukoplakias when screening for this oral precancer. Materials and Methods: Samples of oral leukoplakia (40 cases) and of normal mucosa (10 cases) were evaluated. Oral leukoplakia was graded into: hyperkeratosis without dysplastic change (8 cases), mild dysplasia (13 cases), moderate dysplasia (10 cases), and severe dysplasias (9 cases). Expression of CD44s,v5, v6 was analyzed by immunohistochemistry in a semiquantitative manner. Three areas of epithelium were scored B, S, and C, i.e., stratum basale, stratum corneum, and stratum spinosum, respectively in leukoplakias. Scoring of all specimens followed a two-parameter system, which implemented percentage of positive cells and staining intensities. Statistical analyses for each parameter of all groups and normals, mean, and standard deviation were calculated by using computer software package EPISTAT. Results: In normal epithelium CD44s, CD44v5, and CD44v6 were expressed as membranous proteins localized on the surface of epithelial cells. Both basal and spinous layer of epithelia expressed strong positive staining of CD44s, v5, v6 which then gradually faded into the negative staining of the superficial keratin layer. Profile of CD44s and v5 revealed that the mean levels of stratum B, S, and C in normal cases were comparable to the study cases and by Student ′t′ test P>0.05 not significant. There was, however, a statistically significant decrease in the expression of v6 with increasing grades of dysplasias when compared with normal mucosa. Conclusion: Among CD44s and its variant isoforms,v5, v6, in this study, variant isoform v6 may serve as a marker in detecting high-risk leukoplakias

Ferranti Effect Demonstration And Calculation Of Abcd Parameters

T is necessary to calculate the voltage, current and power at any point on a transmission line provided the values at one point are known. We are aware that in three phase circuit problems it is sufficient to compute results in one phase and subsequently predict results in the other two phases by exploiting the three phase symmetry. Although the lines are not spaced equilaterally and not transposed, the resulting asymmetry is slight andthe phases are considered to be balanced. As such the transmission line calculations are also carried out on per phase basis. For that purpose in the transmission line demo panel we will be designed to –To study the performance of the line

Synthesis and antidiabetic evaluation of some novel compounds

849-854Aryloxypropanolmines have been reported to have β3-agonist activity. Agonists of β3-adrenergic receptors have been observed to simultaneously increase lipolysis, fat oxidation, energy expenditure and insulin action leading to the belief that this receptor might serve as an attractive target for the treatment of diabetes and obesity. Various aryloxypropanolamine derivatives have been synthesized starting with the substituted imines derived from 4-hydroxy benzaldehyde and substituted anilines. These imines have been converted to benzamide intermediates. The benzamide epoxide intermediates have been synthesized using epichlorhydrin. The title compounds 6a-j have been synthesized via ring opening of the epoxides. The synthesized compounds have been characterized using infrared (IR), nuclear magnetic resonance (NMR) and mass spectrometry. The synthesized compounds have been evaluated for antidiabetic activity on streptozotocin induced diabetic male Wistar rats. The synthesized aryloxypropanolamine derivative consisting of –OCH3 and t-butyl amine substituents show good activity as compared to the other synthesized compounds in the series. Glibenclamide has been taken as standard for measuring the antidiabetic activity

Compound odontoma

Odontomas have been extensively reported in the dental literature, and the term refers to tumors of odontogenic origin. Though the exact etiology is still unknown, the postulated causes include: local trauma, infection, inheritance and genetic mutation. The majority of the lesions are asymptomatic; however, may be accompanied with pain and swelling as secondary complaints in some cases. Here, we report a case of a compound odontome in a 14 year old patient

Universal mechanism of luminescence enhancement in doped perovskite nanocrystals from symmetry analysis

Metal-halide perovskite nanocrystals have demonstrated excellent optoelectronic properties for light-emitting applications. Isovalent doping with various metals (M2+) can be used to tailor and enhance their light emission. Although crucial to maximize performance, an understanding of the universal working mechanism for such doping is still missing. Here, we directly compare the optical properties of nanocrystals containing the most commonly employed dopants, fabricated under identical synthesis conditions. We show for the first time unambiguously and supported by first principles calculations and molecular orbital theory that element-unspecific symmetry-breaking rather than element-specific electronic effects dominate these properties under device-relevant conditions. The impact of most dopants on the perovskite electronic structure is predominantly based on local lattice periodicity breaking and resulting charge carrier localization, leading to enhanced radiative recombination, while dopant-specific hybridization effects play a secondary role. Our results suggest specific guidelines for selecting a dopant to maximize the performance of perovskite emitters in the desired optoelectronic devices

Luminescence Enhancement Due to Symmetry Breaking in Doped Halide Perovskite Nanocrystals.

Funder: Gianna Angelopoulos Programme for Science, Technology and InnovationFunder: Engineering and Physical Sciences Research CouncilFunder: Stanford UniversityFunder: Rowland Institute at HarvardMetal-halide perovskite nanocrystals have demonstrated excellent optoelectronic properties for light-emitting applications. Isovalent doping with various metals (M2+) can be used to tailor and enhance their light emission. Although crucial to maximize performance, an understanding of the universal working mechanism for such doping is still missing. Here, we directly compare the optical properties of nanocrystals containing the most commonly employed dopants, fabricated under identical synthesis conditions. We show for the first time unambiguously, and supported by first-principles calculations and molecular orbital theory, that element-unspecific symmetry-breaking rather than element-specific electronic effects dominate these properties under device-relevant conditions. The impact of most dopants on the perovskite electronic structure is predominantly based on local lattice periodicity breaking and resulting charge carrier localization, leading to enhanced radiative recombination, while dopant-specific hybridization effects play a secondary role. Our results suggest specific guidelines for selecting a dopant to maximize the performance of perovskite emitters in the desired optoelectronic devices